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Chiral 1,4-diazepinones and 1,4-thiazepinones by diastereoselective ring chain transformation of α,β unsaturated lactones or lactams

✍ Scribed by J. Bohrisch; H. Faltz; M. Pätzel; J. Liebscher


Book ID
108372206
Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
583 KB
Volume
50
Category
Article
ISSN
0040-4020

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## Abstract α,β‐Unsaturated lactones or lactams 1 react with hydrazines 2 via Michael‐like addition and subsequent ring transformation by nucleophilic attack of the hitherto unchanged hydrazine nitrogen atom at the carbonyl carbon atom. The addition is highly trans‐stereoselective, thus affording o