Chemotherapy of autochthonous leukemias induced by 7,12-dimethylbenz(a)anthracene in long evans rats
✍ Scribed by W. J. Zeller; M. Berger; D. Schmähl
- Book ID
- 112295379
- Publisher
- Springer-Verlag
- Year
- 1980
- Tongue
- English
- Weight
- 294 KB
- Volume
- 96
- Category
- Article
- ISSN
- 1432-1335
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## Abstract This report describes morphological transformations observed approximately 6 weeks after treatment of Rauscher leukemia virus (RLV) infected rat embryo (RE) cells with various levels of 7,12‐Dimethylbenz(a)‐anthracene (DMBA) for 7 days. Uninfected cells treated with DMBA and RLV‐infecte
The 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat leukemia model enables scientists to analyze cells altered by carcinogens at various stages of leukemogenesis. We have reported that a consistent type of point mutation, A→T transversion at the second base in codon 61 of the N-ras gene, was prese
## Abstract The banding pattern of DMBA‐induced leukemias in C57BL/6 mice revealed a very constant chromosome pattern: the presence of trisomy 15 in almost all leukemic cells. This finding strongly suggests that chromosome 15 trisomy is the first detectable specific chromosome change associated wit