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N-ras mutation in 7,12-dimethylbenz[a]anthracene (DMBA)-induced erythroleukemia in long-evans rats

✍ Scribed by Mitsuhiko Osaka; Shinji Matsuo; Takashi Koh; Ping Liang; Hidefumi Kinoshita; Sakan Maeda; Taketoshi Sugiyama

Book ID
116123206
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
951 KB
Volume
91
Category
Article
ISSN
0304-3835

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The 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat leukemia model enables scientists to analyze cells altered by carcinogens at various stages of leukemogenesis. We have reported that a consistent type of point mutation, A→T transversion at the second base in codon 61 of the N-ras gene, was prese