Chemotherapy induces or increases expression of multidrug resistance-associated protein in malignant melanoma cells
β Scribed by N. Ichihashi; Y. Kitajima
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 428 KB
- Volume
- 144
- Category
- Article
- ISSN
- 0007-0963
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Overexpression of the Pβglycoprotein/multidrug resistance 1 __(MDR1)__ and multidrug resistance protein 1 __(MRP1)__ gene is closely associated with the clinical outcome of various malignancies, and it is involved in responses to some anticancer chemotherapeutic agents including doxorub
Multidrug resistance-associated protein-1 (MRP1) is an integral membrane efflux protein that is implicated in multidrug resistance in cancer, but it is also expressed in normal tissues. The objective of this study was to determine the expression, localization and functional activity of MRP1 in prima
The present study characterized the response of P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP1) to chronic ritonavir (RIT) exposure by assessing increases in P-gp and MRP1 protein expression and activity. LS-180V intestinal carcinoma cells were exposed for 3 days to 1Β±100 mM