Chemoselective synthesis of peptides containing major advanced glycation end-products of lysine and arginine
β Scribed by Gruber, P. ;Hofmann, T.
- Book ID
- 110893899
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 235 KB
- Volume
- 66
- Category
- Article
- ISSN
- 1397-002X
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## Abstract The Maillard reaction occurring between sugars and amino groups is important in living systems. When amino groups belonging to protein chains are involved, the Maillard reaction has been invoked as responsible for protein crossβlinking and the production of βtoxicβ compounds. The reacti
Almtract---p-Nitroanilides of N-acylated di-, tri-and tetrapeptides with C-terminal arginine or lysine residues have been obtained, as a rule with good yields, via acylation of arginine or lysine p-nitroanilides by methyl esters of respective N-acylated peptides, catalyzed by subtilisin or ct-ehymot