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Chemopreventive efficacy of selenium against N-nitrosodiethylamine-induced hepatoma in albino rats

✍ Scribed by C. Thirunavukkarasu; J. Prince Vijeya Singh; K. Selvendiran; D. Sakthisekaran

Book ID
101816989
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
101 KB
Volume
19
Category
Article
ISSN
0263-6484

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✦ Synopsis

Abstract

The chemopreventive/chemotherapeutic effect of sodium selenite on tricarboxylic acid cycle key enzymes was investigated against hepatoma induced by environmental carcinogen N‐nitrosodiethylamine. Decreased activities of TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and α‐ketoglutarate dehydrogenase (α‐KGDH) in hepatoma and surrounding tissues of hepatoma‐bearing rats were observed. Upon selenium supplementation the above biochemical changes were reverted in a dose‐ and duration‐dependent manner. This study further confirms the chemopreventive/chemotherapeutic effect of sodium selenite which is found to be more effective in the initiation phase of carcinogenesis. Copyright © 2001 John Wiley & Sons, Ltd.

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Effect of sodium selenite on lipids and
Effect of sodium selenite on lipids and lipid-metabolizing enzymes in N-nitrosodiethylamine-induced hepatoma-bearing rats
✍ C. Thirunavukkarasu; K. Selvedhiran; J. Prince Vijaya Singh; P. Senthilnathan; D 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB

## Abstract As part of a substantial effort to curtail the adverse health effects posed by hepatoma, studies have been conducted to elucidate the possible mechanism for the anticarcinogenic action of sodium selenite against __N__‐nitrosodiethylamine‐induced hepatoma. Several investigations recogniz