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Chemoprevention of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine-induced mammary carcinogenesis in rats

✍ Scribed by Hideki Mori; Shigeyuki Sugie; Wahidor Rahman; Natsuko Suzui

Book ID
117469489
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
72 KB
Volume
143
Category
Article
ISSN
0304-3835

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## Abstract Reduced expression of BRCA1 protein, caused by the hypermethylation of its gene promoter and by other mechanisms, is observed in most sporadic human breast cancers, whereas its somatic mutations are rare. In the present study, we demonstrate that immunoreactivity of __Brca1__ was reduce