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Chemoenzymatic synthesis of CMP-N-acetyl-7-fluoro-7-deoxy-neuraminic acid

✍ Scribed by Sina Hartlieb; Almut Günzel; Rita Gerardy-Schahn; Anja K. Münster-Kühnel; Andreas Kirschning; Gerald Dräger


Book ID
108080511
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
185 KB
Volume
343
Category
Article
ISSN
0008-6215

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Synthesis and Biological Properties of N
✍ Heinz-Werner Hagedorn; Reinhard Brossmer 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 German ⚖ 412 KB

N-Acetylneuraminic acid (1) can be transformed into the methyl a-u-ketoside 2 which, by reaction with methanesulfonyl chloride, yields the corresponding 4-0 mesylate 3 and the 4.7-di-0 -mesylate 4 as a by-product. Compound 3 reacts with Nal giving the 4-dcoxy-4-iodo compound 5 with cquatorial orient