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Chemoenzymatic Synthesis of a New Class of Macrocyclic Oligosaccharides

โœ Scribed by Muthana, Saddam; Yu, Hai; Cao, Hongzhi; Cheng, Jiansong; Chen, Xi


Book ID
111939136
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
664 KB
Volume
74
Category
Article
ISSN
0022-3263

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Chemoenzymatic synthesis of macrocyclic
โœ Wei Lu; Charles J. Sih ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 189 KB

ยฑ)-Azemacrolides were synthesized via lipase-catslyzed intmmolccular cyclization of (~-)-hydroxy-azaesters. Further, the size of the macrocyclic lactones formed could be altered by the substituent on the nitrogen atom. This allows one to prepare a combinatorial library of azamacrolides from a small