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Chemoenzymatic preparation of (6R)-5,6-dihydro-2H-pyran-2-one: a ubiquitous structural motif of biologically active lactones

✍ Scribed by Carrera, Ignacio; Brovetto, Margarita; Seoane, Gustavo A.


Book ID
122183885
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
588 KB
Volume
24
Category
Article
ISSN
0957-4166

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The Stereoselective Total Synthesis of (
✍ Jhillu Singh Yadav; Dandekar Chandrakanth; Yerragorla Gopala Rao; Kontham Ravind 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 German ⚖ 180 KB

## Abstract The stereoselective total synthesis of an antiproliferative and antifungal __α__‐pyrone natural product (6__S__)‐5,6‐dihydro‐6‐[(2__R__)‐2‐hydroxy‐6‐phenylhexyl]‐2__H__‐pyran‐2‐one is described. The key steps involved are the __Prins__ cyclization, __Mitsunobu__ reaction, and ring‐closi