Chemocontrolled reduction of α-keto esters by hydrides: a possible solution for selective reduction of the ester function
✍ Scribed by V. Dalla; J.P. Catteau
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 870 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
ot-hydroxyesters 5a.g or diols 6a.g have been obtained in high yields by reduction of aromatic ot-ketoesters 4 once or twice respectively by using NaBH4 as the reducer under suitable conditions. The use of a solvent that does not interact with the reagent allowed the double reduction to occur with o
An intrumolecular hydride delivery process largely contributes during the double reduction of a-keto esters into diols by NaBH4. In the case of enolic a-keto esters, the first step of the process, the reduction of the keto group, oecured exclusively through an 1,2-hydride addition despite the predom