Chemo- and diastereoselective cyclic ketalization of optically pure 1-aryl-2,2-dimethylpropane-1,3-diols with phenylglyoxal
✍ Scribed by Hu Xianming; Richard M. Kellogg
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 270 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0165-0513
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract In THF solution, NaBH~4~ in the presence of (__S__)‐(‐)‐1‐(2‐chlorophenyl)‐2,2‐dimethylpropane‐1,3‐diol together with 2‐chlorobenzoic acid reduced propiophenone to 1‐ phenylpropan‐1‐ol in up to 40% enantiomeric excess (__ee__). Only 21% __ee__ was obtained without an added acid. (__R__)
Asymmetric Reduction and Meerwein-Ponndorf-Verley Reaction of Prochiral Aromatic Ketones in the Presence of Optically Pure 1-Aryl-2, 2-dimethylpropane-1,3-diols. -The title reactions are carried out in the presence of optically pure 1-aryl-2,2-dimethylpropane-1,3-diols, e.g. CPD and PDP, under vary
## Abstract An economic and practical method for preparing enantiomerically pure [1,1′‐binaphthalene]‐2,2′‐diols is reported. Thus, a condensate of __threo__‐(1__S__,2__S__)‐2‐amino‐1‐(4‐nitrophenyl)propane‐1,3‐diol and cyclohexanone (CHANP) was used as a resolving agent. A 2 : 1 : 1 mixture of rac