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ChemInform Abstract: Toward a Total Synthesis of Pristinamycin IIB; a Chiron Approach to a C-9/C-16 Fragment.

✍ Scribed by P. BREUILLES; D. UGUEN

Publisher
John Wiley and Sons
Year
2010
Weight
39 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Toward a Total Synthesis of Pristinamycin II B ; a Chiron Approach to a C-9/C-16 Fragment.

-Starting from readily available (S)-malic acid derivative (I), an appreciable amount (ca. 2 g) of the title fragment (XV) is prepared using the Grignard reaction of the propargyl diol (VI) as the key step. The regioisomeric products (VIII) and (IX) are separated via their diphenyl-t-butoxysilyl ethers. -(BREUILLES, P.;

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