ChemInform Abstract: Total Synthesis of the Vancomycin Aglycon.
โ Scribed by Dale L. Boger; Susumu Miyazaki; Seong Heon Kim; Jason H. Wu; Steven L. Castle; Olivier Loiseleur; Qing Jin
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 23 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
Total Synthesis of Vancomycin Aglycon. Part 3. Final Stages. -The conversion of the skeletal framework (preceding paper) to the vancomycin aglycon is started by the substitution of the triazene moiety with a hydroxyl group. The triazene moiety is successfully reduced to an amino group by Raney nick
Total Syntheses of Vancomycin and Eremomycin Aglycons. -Vancomycin aglycon (Ia) is obtained in 40 steps (longest linear sequence) from 3,5-dimethoxybenzyl alcohol (via amino acid 7). Eremomycin aglycon (Ib) is also successfully synthesized through an identical strategy. These syntheses provide dias