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ChemInform Abstract: Total Synthesis of Syringolin A.

✍ Scribed by Chunhui Dai; Corey R. J. Stephenson

Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
41
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

The Ξ±,β‐unsaturated ester (I) is prepared starting from L‐valine and the unnatural 3,4‐dehydrolysine fragment (II) starting from Garnerβ€²s aldehyde.

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Total Synthesis of (-)-Epothilone A. -A key step in the synthesis of the title antitumor natural product is the highly stereoselective aldol reaction of the optically active building blocks (I) and (II). Esterification of the product (IV) with the subunit (V) leads to the stereochemically homogeneou