ChemInform Abstract: Total Synthesis of (R)-Dihydroactinidiolide and (R)-Actinidiolide Using Asymmetric Catalytic Hetero-Diels—Alder Methodology.

✍ Scribed by S. YAO; M. JOHANNSEN; R. G. HAZELL; K. A. JOERGENSEN

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199823236

✦ Synopsis

Total Synthesis of (R)-Dihydroactinidiolide and (R)-Actinidiolide Using Asymmetric Catalytic Hetero-Diels-Alder Methodology.

-Key steps in the synthesis of title compounds (V) and (VI) are regio-and stereoselective hetero-Diels-Alder reaction of the diene (I) and subsequent rearrangement to the lactone (IV). The latter is a potent intermediate of related compounds.