Total Synthesis and Absolute Configuration of Polycavernoside A. -The first total synthesis of polycavernoside A (XII), a toxin of red alga species, is presented, involving formation of the cyclic acetal (IV), lactonization of secoic acid (V) and rearrangement of the obtained 12-membered lactone (V
ChemInform Abstract: Total Synthesis of Polycavernoside A
β Scribed by Kenshu Fujiwara; Akio Murai
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 24 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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Total Synthesis of (-)-Epothilone A. -A key step in the synthesis of the title antitumor natural product is the highly stereoselective aldol reaction of the optically active building blocks (I) and (II). Esterification of the product (IV) with the subunit (V) leads to the stereochemically homogeneou