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ChemInform Abstract: Total Synthesis of Madindoline A.

โœ Scribed by Seijiro Hosokawa; Kazuhiko Sekiguchi; Kanako Hayase; Yasushi Hirukawa; Susumu Kobayashi


Publisher
John Wiley and Sons
Year
2000
Weight
28 KB
Volume
31
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Total Synthesis of
โœ D. SCHINZER; A. LIMBERG; A. BAUER; O. M. BOEHM; M. CORDES ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 30 KB ๐Ÿ‘ 2 views

Total Synthesis of (-)-Epothilone A. -A key step in the synthesis of the title antitumor natural product is the highly stereoselective aldol reaction of the optically active building blocks (I) and (II). Esterification of the product (IV) with the subunit (V) leads to the stereochemically homogeneou