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ChemInform Abstract: Total Synthesis of Brevetoxin B. Part 2. Second Generation Strategies and Construction of the Dioxepane Region (DEFG).

โœ Scribed by K. C. NICOLAOU; E. A. THEODORAKIS; F. P. J. T. RUTJES; M. SATO; J. TIEBES; X.-Y. XIAO; C.-K. HWANG; M. E. DUGGAN; Z. YANG; E. A. COULADOUROS; F. SATO; J. SHIN; H.-M. HE; T. BLECKMAN


Book ID
112028066
Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
27
Category
Article
ISSN
0931-7597

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Total Synthesis of Brevetoxin A: Part 2:
โœ K. C. Nicolaou; Paul A. Wallace; Shuhao Shi; Michael A. Ouellette; Mark E. Bunna ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 252 KB ๐Ÿ‘ 2 views

Our second generation strategy for the total synthesis of brevetoxin A involved dissection of the molecule at the ring F oxocene. Synthetically, the F ring formation was expected to occur through Wittig coupling of requisite polycyclic fragments 2 and 3, followed by a hydroxy dithioketal cyclization