investigating the role of amino acids in brown adipose tissue
ChemInform Abstract: The Metabolic Basis of Cancer Cachexia
β Scribed by J. M. ARGILES; B. ALVAREZ; F. J. LOPEZ-SORIANO
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 24 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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A large number of observations point towards cytokines, polypeptides released mainly by immune cells, as the molecules responsible for the metabolic derangements associated with cancer-bearing states. Indeed, these alterations lead to a pathological state known as cancer cachexia which is, unfortuna
## BACKGROUND. Imbalanced amino acid diets in animals rapidly produce anorexia and weight loss. Blockade of type 3 serotonergic receptors (5HT 3 ) can ameliorate anorexia in this animal model. Imbalanced plasma amino acid levels also have been documented in both animal models and human patients wit