A large number of observations point towards cytokines, polypeptides released mainly by immune cells, as the molecules responsible for the metabolic derangements associated with cancer-bearing states. Indeed, these alterations lead to a pathological state known as cancer cachexia which is, unfortuna
The metabolic basis of cancer cachexia
✍ Scribed by Josep M. Argilés; Belén Alvarez; Francisco Javier López-Soriano
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 310 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0198-6325
No coin nor oath required. For personal study only.
✦ Synopsis
investigating the role of amino acids in brown adipose tissue
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Kuper cells (KC), the liver macrophages, are able to produce PGE 2 , which is involved in immune suppression and in the aggravation of cancer cachexia due to interference with lipid metabolism in the liver. Since tumour-bearing (TB) rats present high plasma epinephrine levels, and this hormone is ab