๐”– Bobbio Scriptorium
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Serotonergic blockade in the treatment of the cancer anorexia-cachexia syndrome

โœ Scribed by Martin J. Edelman; David R. Gandara; Frederick J. Meyers; Rie Ishii; Michael O'Mahony; Margaret Uhrich; Ignacio Lauder; Joan Houston; Dorothy W. Gietzen

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
64 KB
Volume
86
Category
Article
ISSN
0008-543X

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โœฆ Synopsis

BACKGROUND.

Imbalanced amino acid diets in animals rapidly produce anorexia and weight loss. Blockade of type 3 serotonergic receptors (5HT 3 ) can ameliorate anorexia in this animal model. Imbalanced plasma amino acid levels also have been documented in both animal models and human patients with cancer cachexia. Therefore a trial of the 5HT 3 receptor antagonist, ondansetron, was undertaken in the treatment of patients with cancer cachexia.

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