Enzymes in Organic Chemistry. Part 5. First and Chemo-Enzymatic Synthesis of α-Aminooxyphosphonic Acids of High Enantiomeric Excess. -Acyloxyphosphonates (I) are resolved by lipase-catalyzed enantioselective hydrolysis with good to excellent enantiomeric excesses, if hydrolysis is stopped at 30-45%
ChemInform Abstract: The First Synthesis of Both Enantiomers of [α-2H]Phenylacetic Acid in High Enantiomeric Excess.
✍ Scribed by Kaori Matoishi; Satoshi Hanzawa; Hitoshi Kakidani; Masumi Suzuki; Takeshi Sugai; Hiromichi Ohta
- Publisher
- John Wiley and Sons
- Year
- 2000
- Weight
- 33 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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New Expedient Route to Both Enantiomers of Nonproteinogenic α-Amino Acid Derivatives from the Unsaturated 2-Aza-bicyclo Moiety. -Unsaturated 2-azabicyclo derivatives (I) give under the indicated conditions amino acid derivatives (II), which after reduction to the amino alcohols can be used as chira