✍ Scribed by M. DRESCHER; F. HAMMERSCHMIDT
No coin nor oath required. For personal study only.
Enzymes in Organic Chemistry. Part 5. First and Chemo-Enzymatic Synthesis of α-Aminooxyphosphonic Acids of High Enantiomeric Excess.
-Acyloxyphosphonates (I) are resolved by lipase-catalyzed enantioselective hydrolysis with good to excellent enantiomeric excesses, if hydrolysis is stopped at 30-45% conversion, and the resulting ester is subjected a second time to lipase hydrolysis. The ( R)-enantiomers (II) are obtained by chemical hydrolization of enriched (R)-esters (I). The title acids (IV) are obtained by treatment of resolved enantiomers (II) under modified Mitsunobu conditions and deprotection of the phthalimido derivatives in two steps follows.
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v