𝔖 Bobbio Scriptorium
✦   LIBER   ✦

ChemInform Abstract: New Expedient Route to Both Enantiomers of Nonproteinogenic α-Amino Acid Derivatives from the Unsaturated 2-Aza-bicyclo Moiety.

✍ Scribed by Diego A. Alonso; Sophie K. Bertilsson; Sandra Y. Johnsson; Sofia J. M. Nordin; Mikael J. Soedergren; Pher G. Andersson

Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
30
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

✦ Synopsis

New Expedient Route to Both Enantiomers of Nonproteinogenic α-Amino Acid Derivatives from the Unsaturated 2-Aza-bicyclo Moiety.

-Unsaturated 2-azabicyclo derivatives (I) give under the indicated conditions amino acid derivatives (II), which after reduction to the amino alcohols can be used as chiral building blocks, e.g. in ligand synthesis of compound (IV). By variation of the hydrogenation conditions, acidity and hydrogen pressure, a control of the extent of allylic vs benzylic C-N hydrogenolysis is possible leading to three other types of products such as (V), (VIII), and (IX). The new approach can also be used for the synthesis of chiral α-amino ketone (VII). -

📜 SIMILAR VOLUMES

ChemInform Abstract: The Asymmetric Synt
ChemInform Abstract: The Asymmetric Synthesis and Conformational Analysis of New C2-Symmetric Macrocycles Derived from Head-to-Head Linked α-Amino Acids and Benzene or Pyridine.
✍ Patrick D. Bailey; Simon R. L. Everitt; Keith M. Morgan; Andrew G. Brewster 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v