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ChemInform Abstract: Tetracyclic Analogues of (+)-S 14297: Synthesis and Determination of Affinity and Selectivity at Cloned Human Dopamine D3 vs D2 Receptors.

✍ Scribed by J.-L. PEGLION; J. VIAN; B. GOUMENT; N. DESPAUX; V. AUDINOT; M. J. MILLAN

Publisher: John Wiley and Sons
Year: 2010
Weight: 38 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199734186

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✦ Synopsis

Tetracyclic Analogues of (+)-S 14297: Synthesis and Determination of Affinity and Selectivity at Cloned Human Dopamine D3 vs D2 Receptors. -Starting from the structure of the preferential D3 antagonist S 14297 a series of cis and trans tetracyclic derivatives are prepared following the routes depicted in the scheme. The trans oxazino derivative (Vb) shows increased affinity at the D3 receptors.

-(PEGLION,

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