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ChemInform Abstract: Synthetic Nucleosides and Nucleotides. Part 35. Synthesis and Biological Evaluations of 5-Fluoropyrimidine Nucleosides and Nucleotides of 3-Deoxy-β-D-ribofuranose and Related Compounds.

✍ Scribed by M. SANEYOSHI; M. KOHSAKA-ICHIKAWA; A. YAHATA; S. KIMURA; S. IZUTA; T. YAMAGUCHI


Book ID
112030681
Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
27
Category
Article
ISSN
0931-7597

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Nucleosides and Nucleotides. Part 155. Synthesis, Antitumor Effects, and Possible Enzymatic Activation Mechanism of 5'-Phosphatidyl-2'deoxy-2'-methylenecytidine (DMDC). -The title compounds (III) are synthesized using an enzyme-catalyzed transphosphatidylation. They show remarkable antileukemic and

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## Abstract The dinucleoside phosphate __Π__~d~p__Π__~d~ (**4**) was synthesized from the monomers 1‐(5′‐__O__‐monomethoxytrityl ‐ 2′ ‐ deoxy ‐ β ‐ D ‐ ribofuranosyl) ‐ 2 (1 __H__) ‐ pyridone ((MeOTr) __Π__~d~, **2**) and 1‐(5′‐__O__‐phosphoryl‐3′‐__O__‐acetyl‐2′‐deoxy‐β‐D‐ribofuranosyl)‐(1__H__)‐p