Novel Synthesis of Nectrisine and 4-epi-Nectrisine. -Nectrisine (VIII), a potent inhibitor of glycosidase, is prepared by a new route starting from D-(-)-diethyl tartrate. Key step is the reduction of a lactam precursor to the amino alcohol. Since all attempts to reduce lactam (IV) are unsuccessful
ChemInform Abstract: Synthesis of Unnatural Enantiomer of Nectrisine and Its Biological Activity.
β Scribed by Naoto Kogoshi; Akira Takatsuki; Yong Jip Kim; Takeshi Kitahara
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 37 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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