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ChemInform Abstract: New Unnatural L-Nucleoside Enantiomers: From Their Stereospecific Synthesis to Their Biological Activities.

✍ Scribed by G. GOSSELIN; V. BOUDOU; J.-F. GRIFFON; G. PAVIA; C. PIERRA; J.-L. IMBACH; A.-M. AUBERTIN; R. F. SCHINAZI; A. FARAJ; J.-P. SOMMADOSSI

Publisher: John Wiley and Sons
Year: 2010
Weight: 39 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199812204

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✦ Synopsis

New Unnatural L-Nucleoside Enantiomers: From Their Stereospecific Synthesis to Their Biological Activities.

-Purine and pyrimidine β-L-dideoxynucleosides (IV) and (V) as well as (X) and (XI) are stereoselectively synthesized and their antiviral properties examined. Derivatives (IV) and (V) are found to have significant anti-HIV and anti-hepatitis B virus activities in cell culture. -(GOSSELIN, G.;

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