ChemInform Abstract: Synthesis of the Marine Dibromooxoindoline Convolutamydine C.
β Scribed by S. MIAH; C. J. MOODY; I. C. RICHARDS; A. M. Z. SLAWIN
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Synthesis of the Marine Dibromooxoindoline Convolutamydine C. -The first synthesis of convolutamydine C (XIII) is described. Key steps are the Rh(II) perfluorobutyramide catalyzed cyclization of diazoamide (V) and the subsequent high yielding one-pot hydrolysis-decarboxylation-oxidation of oxoindoline-3-carboxylate (VIII). -(MIAH, S.; MOODY, C.
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A Modified Sandmeyer Methodology and the Synthesis of (Β±)-Convolutamydine A. -A modified Sandmeyer methodology (lower temperature and addition of ethanol) is found to be useful for the high yield synthesis of Ξ±-isonitrosoacetanilides (III). Derivative (IIIc) is readily converted to (Β±)-convolutamyd
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Microwave-Assisted Preparation of Isatins and Synthesis of (Β±)-Convolutamydine-A. -A microwave assisted synthesis of isostatin derivatives (IV) (8 examples) is reported. Using this new strategy, the alkaloid (Β±)-convolutamydine-A (VI), a potential reagent against leukemia, is synthesized. -(JNANESH