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ChemInform Abstract: Synthesis of Tetrocarcin Derivatives with Specific Inhibitory Activity Towards BcI-2 Functions.

โœ Scribed by Masami Kaneko; Takayuki Nakashima; Yuko Uosaki; Mitsunobu Hara; Shun-ichi Ikeda; Yutaka Kanda


Publisher
John Wiley and Sons
Year
2010
Weight
24 KB
Volume
32
Category
Article
ISSN
0931-7597

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Synthesis and 5ฮฑ-Reductase Inhibitory Activities of Benzofuran Derivatives with a Carbamoyl Group. -5-Carbamoyl (VII) and 6-carbamoyl derivatives (XI) are prepared and found to show inhibitory activity of human 5ฮฑ-reductase. The key step furan ring cyclization occurs by using HCl, cf. product (V),