ChemInform Abstract: Synthesis of Phosphorothioate Esters of L-Phenyllactic Acid as Transition-State Inhibitors of Carboxypeptidase A.
β Scribed by J. M. HILL; G. LOWE
- Book ID
- 112024199
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 30 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Both enantiomers of 2βbenzylβ5βbromoβ4βoxopentanoic acid were prepared utilizing the diazo ketones as the key intermediates. The compounds were assayed for inhibitory activity against carboxypeptidase A (CPA, EC 3.4.17.1). The (__R__)βform is 260βfold more potent than the corresponding
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