Synthesis and Evaluation of Optical 2-Be
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Jing-Yi JIN; Shou-Feng WANG; Wei XUAN; Ji-Wen SHENG; Si-Hong WANG; Guan-Rong TIA
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Article
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2008
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John Wiley and Sons
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English
β 117 KB
## Abstract Both enantiomers of 2βbenzylβ5βbromoβ4βoxopentanoic acid were prepared utilizing the diazo ketones as the key intermediates. The compounds were assayed for inhibitory activity against carboxypeptidase A (CPA, EC 3.4.17.1). The (__R__)βform is 260βfold more potent than the corresponding