A simple and efficient route to monoprotected E-and Z-2-alkylidene-1 ,Zpropanediols was developed. The key step involves an unusual regio-and stereoselective SR2' Mitsunobu reaction of substituted 3-hydtoxy-2methylenealkenoate. We recently reported that 3.4,~tri-0-benzyl-D-glucose could be used as a
✦ LIBER ✦
ChemInform Abstract: Synthesis of Monoprotected 2-Alkylidene-1,3-propanediols by an Unusual SN2′ Mitsunobu Reaction.
✍ Scribed by A. B. CHARETTE; B. COTE; S. MONROC; S. PRESCOTT
- Book ID
- 112028921
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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