ChemInform Abstract: Convenient Synthesis of (Z)-Monoacetates of 2-Alkylidene-1,3-propanediols.
β Scribed by Tsuyoshi Miura; Satoe Umetsu; Daisuke Kanamori; Nanae Tsuyama; Yuki Jyo; Yuya Kawashima; Naka Koyata; Yasuoki Murakami; Nobuyuki Imai
- Publisher
- John Wiley and Sons
- Year
- 2009
- Weight
- 34 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0931-7597
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Stereoselective Synthesis of (Z)-Ξ±-Alkylidene-Ξ³-butyrolactone from 2-Alkyn-1-one. -Reduction of the recently reported (Z)-3-iodo-3-alken-1ones (I) with sodium borohydride gives the corresponding alkenols (II) without loss of stereochemistry. These undergo a Pd(0)-catalyzed cyclization with CO to for