✍ Scribed by Kejiang Hu; Krzysztof E. Krakowiak; Jerald S. Bradshaw; N. Kent Dalley; Guoping Xue; Reed M. Izatt
No coin nor oath required. For personal study only.
of Chiral Azamacrocycles Using the Bis(αchloroacetamide)s Derived from Chiral 1,2-Diphenylethylenediamine.
-Polyazamacrocycles such as (VIII) and (X) are prepared by reaction of the bis(α-chloroacetamide) (VI) with a number of polyamines. The optically pure starting compounds, e.g. (I), are prepared and resolved to its (R,R)-and (S,S)forms according to the Pikul and Corey procedure. The macrocyclic diamides are reduced to form optically active compounds like tetraaza-12-crown-4 (VIII). However, reduction of macrocycles (X) gives a complex mixture of products. The solid state structures of the precursor of (VIII) and (Xb) are determined by X-ray diffraction. -(HU, KEJIANG; KRAKOWIAK, KRZYSZTOF E.;
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Synthesis of Chiral Epoxides from Aldehydes Using Sulfur Ylide Derived from Reduced Product of Baker's Yeast Reduction. -Baker's yeast reduction of the cyclic β-keto esters (I) provides an enantiomerically pure β-hydroxy ester (II) in the presence of sulfur compounds as additives. A sulfur ylide der
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