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ChemInform Abstract: Synthesis of Cephalostatin Analogues by Symmetrical and Non-Symmetrical Routes.

✍ Scribed by Michael Droegemueller; Timo Flessner; Rolf Jautelat; Ulrich Scholz; Ekkehard Winterfeldt

Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis of Cephalostatin Analogues by Symmetrical and Non-Symmetrical Routes.

-Title analogues as (I), (II) and (III) are synthesized either via two approaches: 1. a symmetrical route by regioselective, but not substrate-specific condensation of enamino ketones as in case of (I), followed (if desired) by non-symmetrical functionalization at a latter stage; 2. on a non-symmetrical route by regioselective and substrate-specific coupling of enamino ketones with vinyl azides as in case of (II) and (III). -(DROEGE-

πŸ“œ SIMILAR VOLUMES

Synthesis of Cephalostatin Analogues by
Synthesis of Cephalostatin Analogues by Symmetrical and Non-Symmetrical Routes
✍ Michael DrΓΆgemΓΌller; Timo Flessner; Rolf Jautelat; Ulrich Scholz; Ekkehard Winte πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 422 KB

The synthesis of the cephalostatin-analogous bis-steroidal pyrazines by coupling of enamino ketones (5, 40) with vinyl azides (17a/b) is reported. Furthermore, an improved pyrazines 6, 27a/b and 41 by the transformation of the C 2symmetrical diketone 6 as a central precursor, as well as the procedur