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ChemInform Abstract: Synthesis of 4-Alkyl-Substituted 1,2,3,4-Tetrahydropyrimidin-2-ones by the Biginelli Reaction.

โœ Scribed by A. D. SHUTALEV; N. V. SIVOVA


Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
30
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Alkylation of 1-(3,
โœ Kristina Kantminiene; Zigmuntas Beresnevicius; Gema Mikulskiene; Jan Kihlberg; J ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB ๐Ÿ‘ 1 views

Alkylation of 1-(3,4-Disubstituted Phenyl)-2-thioxo-1,2,5,6tetrahydropyrimidin-4(3H)-ones. -Alkylation of the title compounds (I), (VI), and (IX) results in the formation of S-and N-methylated derivatives. S-methylated products (III), (VII), and (X) are always the major products. In all cases, meth