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ChemInform Abstract: Alkylation of 1-(3,4-Disubstituted Phenyl)-2-thioxo-1,2,5,6-tetrahydropyrimidin-4(3H)-ones.

✍ Scribed by Kristina Kantminiene; Zigmuntas Beresnevicius; Gema Mikulskiene; Jan Kihlberg; Johan Broddefalk

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199925138

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✦ Synopsis

Alkylation of 1-(3,4-Disubstituted Phenyl)-2-thioxo-1,2,5,6tetrahydropyrimidin-4(3H)-ones.

-Alkylation of the title compounds (I), (VI), and (IX) results in the formation of S-and N-methylated derivatives. S-methylated products (III), (VII), and (X) are always the major products. In all cases, methylation at the N-3 atom is accompanied by desulfurization yielding compounds (V), (VIII), and (XI). Further products such as (IV) and (XII) are obtained in small quantities from the alkylation of (I) and

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