ChemInform Abstract: New Groups of Antimycobacterial Agents: 6-Chloro-3-phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 6-Chloro-3-phenyl-2H-1,3-benzoxazine-2,4(3H)-dithiones.
β Scribed by Karel Waisser; Jiri Gregor; Lenka Kubicova; Vera Klimesova; Jiri Kunes; Milos Machacek; Jarmila Kaustova
- Publisher
- John Wiley and Sons
- Year
- 2000
- Weight
- 32 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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Synthesis of New 2-Arylidene-2H-1,4-benzoxazin-3(4H)-ones. -A series of new 2-arylidenebenzoxazinones [cf. (III), (V), (VI); 10 examples in all] are synthesized by condensation of aromatic aldehydes with benzoxazinone (I). Some of the obtained compounds exhibit marked CNS depressant activity in mic
Alkylation of 1-(3,4-Disubstituted Phenyl)-2-thioxo-1,2,5,6tetrahydropyrimidin-4(3H)-ones. -Alkylation of the title compounds (I), (VI), and (IX) results in the formation of S-and N-methylated derivatives. S-methylated products (III), (VII), and (X) are always the major products. In all cases, meth