ChemInform Abstract: Synthesis and Resolution of 1,5-Di-O-benzyl-2,3-O-isopropylidene-4-O-p- methoxybenzyl-myo-inositol
β Scribed by J. GIGG; R. GIGG
- Book ID
- 112040524
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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An improved procedure for the preparation of 1,2-O-isopropylidene-nqVo-inositol is described. Racemic 1,4-di-O-benzyl-2,3-O-isopropylidene-myo-inositol was prepared by tinmediated benzylation of 1,2-0-isopropylidene-myo-inositol and resolved readily by crystalk sation of the o-camphanates. The use o
An efficient method for the resolution of 1,2:4,5-di-O-isopropylidene-myo-inositol has been developed. The diketal was converted to diastereomeric 3,6-di-O-mandelates by the reaction with (S)-O-acetylmandeloyl chloride. Both the diastereomers could be separated by sequential crystallization in multi