𝔖 Bobbio Scriptorium
✦   LIBER   ✦

ChemInform Abstract: Synthesis and Receptor Binding Affinity of Conformationally Restricted Retinoic Acid Analogues.

✍ Scribed by M. F. WONG; J. J. REPA; M. CLAGETT-DAME; R. W. JUN. CURLEY

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
29
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

✦ Synopsis

Synthesis and Receptor Binding Affinity of Conformationally Restricted Retinoic Acid Analogues.

-Efforts to synthesize two conformationally restricted retinoids utilizing a cyclopropyl ring as bioisostere for the C9-C10 double bond are described. The attempted synthesis of the cisisomer leads mainly to unidentified products and the unexpected epimerization to the trans-derivative (VII). The latter is synthesized independently starting from the cyclopropane (I). -(WONG, M.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Synthesis of Novel
ChemInform Abstract: Synthesis of Novel Conformationally Restricted L-Glutamate Analogues.
✍ S. G. PYNE; K. SCHAFER; B. W. SKELTON; A. H. WHITE πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 37 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

ChemInform Abstract: Conformationally Re
ChemInform Abstract: Conformationally Restricted Analogues of Nicotine and Anabasine.
✍ J.-M. VERNIER πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 27 KB πŸ‘ 2 views

Conformationally Restricted Analogues of Nicotine and Anabasine. -A series of conformationally restricted analogues of nicotine, e.g. (V) and (VIII), are synthesized according to the scheme. In addition, compound (Va) is resolved into its enantiomers using D-di-p-toluoyltartaric acid. The biologica