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ChemInform Abstract: Synthesis and Protein Tyrosine Phosphatase Inhibitory Activity of Dephostatin Analogues.

✍ Scribed by T. WATANABE; T. TAKEUCHI; M. OTSUKA; S. TANAKA; K. UMEZAWA


Book ID
112032840
Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
27
Category
Article
ISSN
0931-7597

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The synthesis of natural product, dephostatin, is described. Both dephostatin and N-methyl-Nnitrosoaniline are found to inactivate the homogeneous recombinant Yersinia and mammalian protein tyrosine phosphatases in a concentration and lime dependent manner. The tyrosine phosphorylation on target pr