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ChemInform Abstract: Synthesis and in vitro Cytotoxicity of Hexacyclic Camptothecin Analogues.

โœ Scribed by Sang-sup Jew; Hee-Jin Kim; Myoung Goo Kim; Eun-Young Roh; Chung Il Hong; Joon-Kyum Kim; Jun-Hee Lee; Heesoon Lee; Hyeung-geun Park


Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
31
Category
Article
ISSN
0931-7597

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## 2. Synthesis and in vitro Cytotoxicity of 5-C-Substituted 20(S)-Camptothecin Analogues. -A series of several 5-substituted camptothecin analogues [cf. (II), (IV), (VI)] are synthesized from the natural alkaloid (I) and evaluated for their in vitro anticancer activity. Some of these analogues, e