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ChemInform Abstract: Synthesis and in vitro Cytotoxic and Antiviral Activities of 1-(2,5,6-Trideoxy-6-halogenohept-5-enofuranurononitrile)thymine and Derivatives.

✍ Scribed by Jean M. J. Tronchet; Frederic Chalard; Elisabeth Rivara-Minten; Michel Seman; Erik De Clercq; Jan Balzarini; Pierre Dilda

Publisher: John Wiley and Sons
Year: 2010
Weight: 29 KB
Volume: 33
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200235215

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Synthesis and Cytotoxic Activities of 6-Chloro-7-arylamino-5,8isoquinolinediones. -A convenient method for the synthesis of the title isoquinolinediones (VI) (12 examples) starting from commercially available 5-nitroisoquinoline (I) is given. These new isoquinoline derivatives, especially the oxyph