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ChemInform Abstract: Synthesis and Cytotoxic Activities of 6-Chloro-7-arylamino-5,8-isoquinolinediones.

✍ Scribed by Chung-Kyu Ryu; In-Kyung Lee; Sung-Hee Jung; Chong-Ock Lee

Publisher: John Wiley and Sons
Year: 2010
Weight: 29 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199932142

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✦ Synopsis

Synthesis and Cytotoxic Activities of 6-Chloro-7-arylamino-5,8isoquinolinediones.

-A convenient method for the synthesis of the title isoquinolinediones (VI) (12 examples) starting from commercially available 5-nitroisoquinoline (I) is given. These new isoquinoline derivatives, especially the oxyphenylamino derivatives, are potent cytotoxic agents against

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Synthesis and Pharmacological Activity of Substituted Amides of 2-Chloro-and 2-Arylamino-5,6-trimethylene(5,6tetramethylene)isonicotinic Acids. -Several novel alkyl-and arylamides of the title isonicotinic acids (III), (V), (VII), (VIII), and (XI) are prepared starting from acids (I) and (IX) by ami