ChemInform Abstract: Synthesis and Pharmacological Activity of Substituted Amides of 2-Chloro- and 2-Arylamino-5,6-trimethylene(5,6-tetramethylene)isonicotinic Acids.

✍ Scribed by T. A. Smirnova; M. Yu. Gavrilov; F. Ya. Nazmetdinov; L. P. Drovosekova; M. E. Kon'shin; V. E. Kolla

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199931178

✦ Synopsis

Synthesis and Pharmacological Activity of Substituted Amides of 2-Chloro-and 2-Arylamino-5,6-trimethylene(5,6tetramethylene)isonicotinic Acids. -Several novel alkyl-and arylamides of the title isonicotinic acids (III), (V), (VII), (VIII), and (XI) are prepared starting from acids (I) and (IX) by amidation of the corresponding acid chlorides followed [in the case of 2-arylamino derivatives (V) and (VIII)] by arylamination in isoamyl alcohol. The synthesized compounds possess neither antispasmodic nor antiinflammatory activity. Only derivatives (XIb) and (VIIIa) show an analgesic effect. -(SMIRNOVA, T. A.; GAVRILOV, M.