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ChemInform Abstract: Synthesis and Evaluation of 6-(Dibromomethyl)-5-nitropyrimidines as Potential Antitumor Agents.

โœ Scribed by M. D. THOMPSON; T. L. CUPPS; D. S. WISE; L. L. WOTRING; L. B. TOWNSEND

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
28
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Synthesis and Evaluation of 6-(Dibromomethyl)-5-nitropyrimidines as Potential Antitumor Agents.

-A series of title compounds is synthesized, in case of (IX), (X), and ( XI) by unexpected substitution of the 4-methoxy group of (VII). Compound (X) and, especially, compound (XI) show good antiproliferative activity in vitro. Unfortunately, their antileukemic activity is overshadowed in vivo by toxicity. -(THOMPSON, M. D.; CUPPS,

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