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ChemInform Abstract: Synthesis of Some 5′-Thiopentofuranosylpyrimidines as Potential Antitumor Agents.

✍ Scribed by F. GIRARD; S. LEONCE; L. A. AGROFOGLIO

Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis of Some 5'-Thiopentofuranosylpyrimidines as Potential Antitumor Agents.

-The synthesis of 5'-sulfur-substituted thymidine analogues is achieved by nucleophilic displacement of the 5-chloro derivative (II) and subsequent oxidations and catalytic hydrogenations. None of these compounds show inhibition of L1210 cells proliferation except (IVb) which is weakly active.

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ChemInform Abstract: Synthesis and Evalu
ChemInform Abstract: Synthesis and Evaluation of 6-(Dibromomethyl)-5-nitropyrimidines as Potential Antitumor Agents.
✍ M. D. THOMPSON; T. L. CUPPS; D. S. WISE; L. L. WOTRING; L. B. TOWNSEND 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

Synthesis and Evaluation of 6-(Dibromomethyl)-5-nitropyrimidines as Potential Antitumor Agents. -A series of title compounds is synthesized, in case of (IX), (X), and ( XI) by unexpected substitution of the 4-methoxy group of (VII). Compound (X) and, especially, compound (XI) show good antiprolifer