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ChemInform Abstract: Synthesis and Cytotoxic Activity of 1-Alkoxy- and 1-Amino-2-hydroxy-1,2-dihydroacronycine Derivatives.

✍ Scribed by Prokopios Magiatis; Sofia Mitaku; Alexios-Leandros Skaltsounis; Francois Tillequin; Michel Koch; Alain Pierre; Ghanem Atassi

Publisher: John Wiley and Sons
Year: 2010
Weight: 32 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199946202

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✦ Synopsis

Synthesis and Cytotoxic Activity of 1-Alkoxy-and 1-Amino-2hydroxy-1,2-dihydroacronycine Derivatives.

-In order to get more information about the structure-activity relationships, a novel series of acronycine derivatives such as (I) and (II) (16 examples) are synthesized. The most active substance (Ib) inhibits the proliferation of L-1210 cells with an IC 50

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